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Alcohol and Tylenol (or other pain relievers) Don't Mix ... health.williams.edu Ibuprofen acetaminophen alcohol Taking acetaminophen (aka Tylenol) can lead to liver damage both acetaminophen and alcohol utilize glutathione in the liver to temper their toxic effects. Over time FL Author: Chris Crawford Phone: (352) 771-2700 Alcohol and Tylenol (or other pain relievers) Don't Mix ... AcetaminophenAlcohol and Tylenol (or other pain relievers) Don't Mix. Acetaminophen (Tylenol) is an antipyretic (fever reducer) and analgesic (pain reliever). Large doses or long-term usage can cause liver damage. Alcohol ic beverages increase the chance of liver toxicity from acetaminophen this me… ACETAMINOPHEN; DIPHENHYDRAMINE is a pain reliever antihistamine combination. It is used to treat allergy symptoms like sore throat ... Is Acetaminophen Safe to Take When You’re Drinking ... AcetaminophenLike acetaminophen but not all alcohol ic drinks are created equal. 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